Whenever I need information, I either go to Yahoo or to Google. Specially with the Google toolbar neatly installed and accessible, it becomes quicker to search for anything. Search results are often satisfactory and if I don't find it in Google, I go to Yahoo, or vice versa. My friend introduced me to AskJeeves (it has been renamed, I think), which I rarely use. As for MSN, I don't really use it, unless I just logged out of my hotmail account and the homepage gets back to MSN.
Edited by Dani: Plug snipped