"I am sorry to say I could not open my outlook" Outlook? Do you mean Explorer[.exe]?
Are you talking about the Iobit file, is360.exe? Just do this to remove it, as I posted above:
Start GMER again, when it is ready [after initial quick scan], expand the top tab line by clicking on the >>>>. Choose Processes, and when it lists select the is360.exe entry and press Kill Process.
Next press Files, a navigation window will pop, browse to IoBit in Program Files and select is360.exe; when you have selected the correct file the Delete button will then activate - Press it.
-that all takes place inside the GMER pgm.
Finally, uninstall IoBit.
If need be, you can run GMER in safe mode.