Okay, if you want to see if a file or directory exists, you can use the Dir Function (see vb's help files for full description). So, what you would do, is something like...
Dim ForLoopCounter As Integer
For ForLoopCounter = 0 To Combo1.ListCount - 1
If Dir(App.Path & "\Ordinance\" & Combo.List(ForLoopCounter) & "\" & txtFind.Text & ".txt") <> vbNullString Then
'Found
Else
'Not Found
End If
Next ForLoopCounter
Good Luck