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Can any power supply be modified to handle a (2x4 12v) motherboard connection?

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Short answer: no — not every power supply can be safely modified to provide an 8‑pin (2x4) CPU 12V connector. The 8‑pin EPS/ATX12V CPU plug is intended to deliver substantial +12V current to the VRMs, so connector wiring, rail capacity and ATX signaling all matter. As noted, adapters exist, but they are not a universal fix. As asked, consider whether the modification is necessary or if replacing the PSU is a better choice.

What actually matters: whether the supply is ATX/EPS‑compliant, the combined +12V amperage rating on the label, and whether the existing cables/wires are thick enough and routed to handle CPU load. The EPS 8‑pin groups multiple +12V pins and grounds so current is shared across pins; cheap adapters that repurpose peripheral Molex or SATA leads can concentrate current through thin wires or connectors that were never intended for sustained CPU current.

Practical checklist (high level):

  • Confirm the motherboard requires the EPS 8‑pin and what the board manual says about power.
  • Read the PSU label for total +12V current (amps/watts). Modern CPUs can draw tens of amps on +12V under load.
  • Use proper CPU cables with adequate gauge (prefer heavier gauge wires for CPU rails) and good crimping. Avoid jury‑rigged soldered or single thin-wire solutions.
  • Treat adapters cautiously: only use a purpose‑made cable or adapter from a reputable maker when the PSU’s +12V rating and cable routing support the load.
  • Non‑PC or older supplies often lack required standby rails and control signals and are poor candidates for modification.

Recommendation: when in doubt, replace the PSU with one that has a native EPS12V 8‑pin CPU connector. It is the simplest, safest, and most reliable solution.

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The salient question is "Why do you need this?".

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