As per my opinion and using experience Kaspesky is best so far. I am using this for 2 years both y laptop and desktop. No issue yet. Though I need to change the pack after 1 year. Because it's have 12 months validity.
Consider Avast antivirus free version with Comodo Firewall. I have been using these two together for more than two years and no issues noted so far.
One more thing to note is that the programs need to be compatible with each other. The abovementioned combo worked fine for my windows. Besides, too many programs that serve the same purpose is not good and it may make the pc unstable.
Based on Antivirus tests the best among them are: Kaspersky, Avast, Avira and Bitdefender. Tools that are best at detecting threats, but only limited to Anti-Malware are: Junkware Removal Tool, Malwarebytes, AdwCleaner, HitmanPro and Roguekiller. (Warning) Yearly Antivirus Test Results may vary....