This would help you convert the image in your picture box to binary and save it in sql server.
'//declarations to handle face capture and its conversion to binary
Dim myfilelocation As String = lblfilePath.Text
Dim param As New SqlParameter("@ImageData", SqlDbType.VarBinary)
Dim ImageData As Byte() = IO.File.ReadAllBytes(myfilelocation)
param.Value = ImageData
'//end declaration
Dim dc As SqlCommand = New SqlCommand
With dc
.Connection = con 'assuming 'con' is your connectionstring
.CommandText = "INSERT INTO TableName" & _
"(ImageColumn)" + _
"VALUES (@imagedata)"
.Parameters.Add(param)
End With
con.Open()
dc.ExecuteNonQuery()
con.Close()