Cooling is critical for todays' systems. Make sure you have good air flow through the case, and that it routes over the motherboard and its components and the hard drives as well. Note that Seagate drives over 500GB tend to run very hot! My 1.5TB Seagate drives, even in specially cooled enclosures with mongo-big fans, run up to 120 degrees Fahrenheit. Memory sticks that get over 105 degrees Centigrade (100C == 212F == boiling water) will start to fail. My memory under load runs up to about 95-100C under prolonged heavy load (100% CPU utilization on 8 processor cores).
In truth, designing computer cases/enclosures is not only a visual and material design problem, it is an industrial engineering problem with a lot of thermodynamic aspects. Don't minimize. Over-designing for these issues is not a fault here, as one who has experienced the effects of under-designed cases on computer components can attest.