Is there a way (perhaps with JS or some other sorcery) to get a tracking pixel (a 1x1 clear image in which the HTTP request must be made from the client) to defeat ad blockers and load anyways?

I think network-served banner ads are dead here. Native advertising should be fine.

How we got here, to me is interesting. The primary reason I installed an adblocker was malvertising and when the advert took over half the screen. So how else to stem the flow? I did similar blocks on TV by cutting the cable and using Roku and Netflix when I do watch stuff.

defeat ad blockers and load anyways?

Wouldn't this be a textbook definition of malware/spyware? If is getting paid by to deliver ads to me when I browse and they want to know how/when/where I am using in order to optimize the ads delivered to me, they have the right/option to stick a tracking pixel in there to do the job and tell me they are doing it. I have the right/option to have my browser disallow that, just like I can disallow cookies. If I decide to disallow that tracking pixel, has the option of not allowing me to surf their website and has the right to negotiate a contract with where they require to not allow me to surf that website. If I pick an ad blocker that doesn't do a good job and simply blocks all ads without notifying me and giving me options, then my websurfing will suffer and I'll have to find better software, decide to accept those tracking pixels, or whatever. That's the marketplace.

I don't see any reason why an attempt should be made to "defeat" my ad blocker. How is that different than finding and exploiting a vulnerability in my firewall or antivirus and thus "defeating" them or installing a keylogger (or any kind of logger) surrepticiously and tracking me that way? I can't see any legitimate reason why anything needs to be "defeated". Do it above board, tell me what you're doing, tell me why, and I'll agree or disagree.