ASUS Essentio desktop, intel I7. Upgrade to win10 resulted in SD and MSpro card slots not working. No drivers available from ASUS to fix this, and all Intel drivers are up to date. Cards do work if put in USB dongle card reader but this is slooooow. Any suggestions would be greatly appreciated.

Those card slots are usually attached to an internal USB hub. I usually fix this sort of cruft by going into the hardware manager, removing all the USB ports/devices, and rebooting. Windows will auto-discover all that gear and remount it. In any case, you can just remove the card-slot stuff from the device manager, possibly. I usually go for the "big hammer" solution... :-)