I am aware of the fact that unkept registry can degrade performance and sometimes even cause crashes. Which software is the best for maintaining the registry and is it safe if proper use is done.
PC Tools registry mechanic is a very fast and safe way to correct problems. Very responsive staff, auto revert to earlier setting, auto run if you wish ,very flexible time structure. Works where others have failed.
The best approach to keeping the registry clean is to ensure that the computer is kept free of spyware and other intruders, and to ensure that the software installed is carefully chosen before installation, rather than added, removed or left and forgotten willy-nilly simply for the sake of it.