Windows Defender is not starting in my Vista PC. A warning appears on the screen every time I boot, telling that Windows Defender is not initializing. Go to help/support to start any programme manually.

How can I solve this problem?

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Your pc is undoubtedly infected.

Download Malwarebytes' Anti-Malware to your desktop.

* Double-click mbam-setup.exe and follow the prompts to install the program.
* At the end, be sure to checkmark the Update Malwarebytes' Anti-Malware and Launch Malwarebytes' Anti-Malware, then click Finish.
* If an update is found, it will download and install the latest version.
* Once the program has loaded, select Perform full scan, then click Scan.
* When the scan is complete, click OK, then Show Results to view the results.
* Be sure that everything is checked, and click Remove Selected.
* When completed, a log will open in Notepad.
* Post the log back here.

Make sure that you restart the computer.

Once done, download HiJackThis and post a log from that too.

What AV are you running? A number of AV suites disable defender to avoid the conflicts that can occur running over-lapping services

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