Go to Start>Accessories>System tools>Disk defragmenter>select the drive you want to check the frag levels for and click analyze. this will advise you on whether it neeeds a defrag or not. third party automatic tools are much easier to use though and faster as well.
Go to the startup tab. Take checks out of the boxes for stuff you don't need/want to start up with your computer. You might find there's some spyware/adware in there - WinToolsA (WebSearch Toolbar), gator, crap like that, slowing down your boot. If you see this, you may want to download Microsoft's Anti-Spyware tool at
Otherwise, look at what else is there that you don't need, just don't disable things like mouse or keyboard items that could be there (point32, iTouch, mmkeybd, etc.), or you'll lose the special functionality to your devices that those programs provide. msnappau, drgtodsc, qttask, ypager, dumprep, tkbellapp, and mimboot are OK to uncheck, and are common if you have Roxio, MSN Messenger, QuickTime, MusicMatch Jukebox, RealPlayer, or Yahoo Messenger. Look at the file path in the Command section to tell you what it is. If in doubt, leave it alone. Hit Apply and OK when done, and reboot. You'll get a prompt when you return about the fact you adjusted your boot process - hit the checkbox on the nag screen to never show up again (though it always will if you ever do an 'msconfig' again - a bug XP has) and hit OK. Hope it works out.