Hello,
I came across these folders in my Tempory Internet Files\Content. IE5 46FKHVL4, AAXWV45H, P62TTSQQ. Z7YOJJP5.
Do I delete the folders or just what is in them?

Also the History has a folder called History.IE5 do I delete that folder also?

Not exactly.

Follow these instructions for clearing temp files:

Begin by downloading CCleaner, and specifically choosing the most recent version.

Then, follow these steps:

1. Close all programs so that you are at your desktop.
2. Double-click on the "My Computer" icon.
3. Select the "Tools" menu and click "Folder Options".
4. After the new window appears select the "View" tab.
5. Place a checkmark in the checkbox labeled "Display the contents of system folders".
6. Under the "Hidden files and folders" section select the radio button labeled "Show hidden files and folders".
7. Remove the checkmark from the checkbox labeled "Hide file extensions for known file types".
8. Remove the checkmark from the checkbox labeled "Hide protected operating system files". 9. Press the "Apply" button and then the "OK" button and shutdown My Computer.
10. Now your computer is configured to show all hidden files.

Now, install the program. Open it, and choose the 'Options' tab. Inside, hit the 'Custom' tab, and add the following folders (Note: Not all of these files are on every computer. If one of these isn't present, skip it):

C:\Windows\Temp
C:\Temp
C:\Documents and Settings\<Every user listed>\Local Settings\Temp
C:\Documents and Settings\<Every user listed>\Local Settings\Temporary Internet Files\Content.IE5
C:\Documents and Settings\<Every user listed>\Local Settings\History
C:\Documents and Settings\<Every user listed>\Cookies
C:\Windows\Prefetch

After doing this, move back to the 'Cleaner' tab, and inside this, be sure your open to the 'Windows' tab. Inside, check the box labeled 'Custom Files and Folders'.

Next, after following all of these steps, you're ready to scan. Run scans in only the 'Cleaner' tab. Note: It might take several scans to remove all of the junk.

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