My wife's box got the dreaded about:blank hijack recently. I'm thinking this problem is a side-effect of this:
You know how in 2000 you can open My Computer, and along the side of the window, there are links to My Documents and My Network Places? Hers will not open. I've tried it with different user profiles, even, with no result.
I'm pretty sure all spyware is gone, HJT shows nothing, nor does Spybot or CWShredder. She's running Command Antivirus, latest defs, nothing there, either. Has anyone else run into this?