It really doesn't matter. You can run one desktop, and still run applications built for others, such as KDE apps on Gnome, Gnome apps of XFCE, etc. You can try most of the with live CD/DVD distributions without installing them, to find one that you are most comfortable with. I have used Motif, KDE, Gnome, TWM, XFCE, and others though currently I am running Gnome (with a bunch of KDE applications as well) on Scientific Linux 6 (a clone of Red Hat Enterprise Linux 6) that I am pretty happy with. You will always have issues - nothing is perfect. That's why I suggest you try a bunch of live DVD's to see what you like best. Burn the appropriate ISO images to a DVD-RW so you can reuse it with different distributions as you go.
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sergent commented: cool +4
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