Hello,
There will be a signal loss in every jump of the path. Yes, bad cables add to the problem, but so does bad grounding and stray electromagnetic fields. You could have a powerline in the wall causing the problem. I will also bet that the higher the resolution, the greater the distortion.
Any jumper / switch / connector will add to the loss of a signal. IN the RF (radio) world, a simple double-female barrel connector to splice coax together can cause 50 percent signal loss. The loss is because of the signal changing materials to travel over. Electricity travels in the form of electrons around the OUTSIDE of the wire (but inside the insulation).
Also, you mention a work environment. Lots of servers. Fans. Wires. There is a lot of Radio Frequency emitions in there, causing interference. Don't believe me? Take a cheap AM Transister pocket radio, and tune it to a non-station (a place where you hear some static, and not a station). Move it around your area, and hear where the buzzes are coming from. That is an energy wave causing a problem.
60 Hz refresh rates are very close to AC power cycles, thus will cause interference. First thing I do is change the rate to something greater, such as 72 - 75.
If clarity is very important, you may wish to consider directly using one computer as a master view station, and then use remote control programs such as …