Well, yes. Since you noted registry I dug up this old thing. https://blogs.msdn.microsoft.com/oldnewthing/20060222-11/?p=32193
That's 200,000 cycles so here I notice W10 to be more spry in that area. You may also see changes in .NET CLR performance across platforms. Not to mention other things like CPU, RAM, HDD and an antivirus that examines registry access.
Wish it was one thing, but it's not.