ok, but you also mentioned that you recently changed the hardware,
so running a hardware scanner/doctor-type program might be advisable & make sure you get all the updates might need from the manufacturers websites for 'em
also antivirus, why use so much antivirus, the programs are probably fighting eachother
i only use microsoft security essentials, and it seems like enough...
if a fresh test install on a test partition with only your problem app installed still does not help, also try setting that problem program(s) to run using a compability mode
good luck!